Two dead as New York City buildings collapse after gas blast
Twenty others have been injured in the incident, which sent smoke billowing into the city sky.
More than 250 firefighters are tackling the blaze at the scene near 116th Street and Park Avenue.
All train services in and out of Grand Central terminal have been halted following the incident near its tracks.
Missing people
New York City Mayor Bill de Blasio said in a news conference from the scene that the gas leak had been reported to the utility company just 15 minutes before the blast on Wednesday morning.
The area is engulfed in thick choking smoke, says the BBC's Nick Bryant at the scene
Mr de Blasio said the "major explosion" had destroyed two buildings and heavily damaged other structures.
At least a dozen individuals were still missing in the area as of Wednesday afternoon, US media report.
"Every effort is being expended to locate" them, Mr de Blasio said.
New York fire department has elevated the incident to the highest threat level possible.
Among the injured was a child said to be in a critical condition, CNN reports.
The utility company, Con Edison, says a resident in a nearby building reported smelling gas shortly before the explosion.
Streets and pavements around the site were littered with broken glass from shattered windows.
Witnesses reported the powerful blast knocked items off shelves in nearby stores.
Authorities in the area were said to be handing out medical masks to residents due to the thick white smoke at the scene.
Eyewitness Shane Kennedy said he heard a "massive explosion"
A witness told the BBC "there was just a lot of panic" following the explosion.
Dan Scarvino had just emerged on to a nearby train platform when "suddenly a plume of smoke came out of nowhere".
"I've never seen anything like it," he added.
A witness told the New York Daily News she had smelled gas "for weeks" before the explosion.
"We saw people flying out of the window... those are my neighbours," Ashley Rivera said.
Another witness told the newspaper he heard two loud explosions that shook the barber shop where he works.
"It was loud, like boom, boom!" Mitch Abreu said. "It rocked the whole block.
"A window blew out of the other shop down the street," he added.
"It looked like the [Twin] Towers all over again. People covered in dust and covering their mouths."
Source:BBC
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